Cyclodextrins Allow the Combination of Incompatible Vancomycin and Ceftazidime into an Ophthalmic Formulation for the Treatment of Bacterial Keratitis

Cyclodextrins Allow the Combination of Incompatible Vancomycin and Ceftazidime into an Ophthalmic Formulation for the Treatment of Bacterial Keratitis

Ceftazidime (CZ) and vancomycin (VA) are two antibiotics used to treat bacterial keratitis. Due to their physical incompatibility (formation of a precipitate), it is not currently possible to associate both molecules in a single container for ophthalmic administration. We firstly characterized the i...

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Bibliographic Details
Main Authors: Yassine Bouattour, Florent Neflot-Bissuel, Mounir Traïkia, Anne-Sophie Biesse-Martin, Robin Frederic, Mouloud Yessaad, Mireille Jouannet, Mathieu Wasiak, Philip Chennell, Valerie Sautou
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
cyclodextrins
vancomycin
ceftazidime
ophthalmic solution
bacterial keratitis
nuclear magnetic resonance
Online Access:https://www.mdpi.com/1422-0067/22/19/10538

Internet

https://www.mdpi.com/1422-0067/22/19/10538

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