Powerful and Real-Time Quantification of Antifungal Efficacy against Triazole-Resistant and -Susceptible Aspergillus fumigatus Infections in Galleria mellonella by Longitudinal Bioluminescence Imaging

Powerful and Real-Time Quantification of Antifungal Efficacy against Triazole-Resistant and -Susceptible Aspergillus fumigatus Infections in Galleria mellonella by Longitudinal Bioluminescence Imaging

ABSTRACT Aspergillus fumigatus is an environmental mold that causes life-threatening respiratory infections in immunocompromised patients. The plateaued effectiveness of antifungal therapy and the increasing prevalence of triazole-resistant isolates have led to an urgent need to optimize and expand...

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Bibliographic Details
Main Authors: Eliane Vanhoffelen, Lauren Michiels, Matthias Brock, Katrien Lagrou, Agustin Reséndiz-Sharpe, Greetje Vande Velde
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
Galleria mellonella
Aspergillus fumigatus
antifungal screening
bioluminescence imaging
triazole resistance
antifungal therapy
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00825-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00825-23

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