Downregulation of microRNA-448 inhibits IL-1β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3

Downregulation of microRNA-448 inhibits IL-1β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3

Abstract Background Osteoarthritis is characterized by the continuous degradation of the articular cartilage. The microRNA miR-448 has been found to be broadly involved in cellular processes, including proliferation, apoptosis, invasion and EMT. While aberrant expression of miR-448 has been found in...

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Bibliographic Details
Main Authors: Hao Yang, Di Wu, Hua Li, Nan Chen, Yongjun Shang
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
Osteoarthritis
MicroRNA-448
Interleukin-1 beta
Chondrocyte
Extracellular matrix
Matrilin-3
Online Access:http://link.springer.com/article/10.1186/s11658-018-0072-6

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http://link.springer.com/article/10.1186/s11658-018-0072-6

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