DNA Sequencing of CD138 Cell Population Reveals TP53 and RAS-MAPK Mutations in Multiple Myeloma at Diagnosis

DNA Sequencing of CD138 Cell Population Reveals TP53 and RAS-MAPK Mutations in Multiple Myeloma at Diagnosis

Multiple myeloma is a hematologic neoplasm caused by abnormal proliferation of plasma cells. Sequencing studies suggest that plasma cell disorders are caused by both cytogenetic abnormalities and oncogene mutations. Therefore, it is necessary to detect molecular abnormalities to improve the diagnosi...

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Bibliographic Details
Main Authors: Mihaela Dragomir, Onda-Tabita Călugăru, Bogdan Popescu, Cerasela Jardan, Dumitru Jardan, Monica Popescu, Silvia Aposteanu, Sorina Bădeliță, Gabriela Nedelcu, Cătălin Șerban, Codruța Popa, Tatiana Vassu-Dimov, Daniel Coriu
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
multiple myeloma
NGS
plasma cells
Online Access:https://www.mdpi.com/2072-6694/16/2/358

Internet

https://www.mdpi.com/2072-6694/16/2/358

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