Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway

Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection that often results in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). An emerging mechanism of sepsis-induced ARDS involves neutrophils/macrophages undergoing cell death, releasing nu...

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Bibliographic Details
Main Authors: Yuzi Tian, Patrick Li, Zhenyu Wu, Qiufang Deng, Baihong Pan, Kathleen A. Stringer, Hasan B. Alam, Theodore J. Standiford, Yongqing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
citrullinated histone H3 (CitH3)
sepsis
acute lung injury
Caspase-1 (CASP1)
inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.761345/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.761345/full

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