Pharmacological Effects of Panduratin A on Renal Cyst Development in In Vitro and In Vivo Models of Polycystic Kidney Disease

Pharmacological Effects of Panduratin A on Renal Cyst Development in In Vitro and In Vivo Models of Polycystic Kidney Disease

Renal cyst expansion in polycystic kidney disease (PKD) involves abnormalities in both cyst-lining-cell proliferation and fluid accumulation. Suppression of these processes may retard the progression of PKD. Evidence suggests that the activation of 5′ AMP-activated protein kinase (AMPK) inhibits cys...

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Bibliographic Details
Main Authors: Kanlayanee Tonum, Nipitpon Srimai, Napason Chabang, Somsak Fongsupa, Patoomratana Tuchinda, Jacob A. Torres, Thomas Weimbs, Sunhapas Soodvilai
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
ADPKD
cystogenesis
AMP-activated protein kinase (AMPK)
cell proliferation
cystic fibrosis transmembrane conductance regulator (CFTR)
renal fluid secretion
Online Access:https://www.mdpi.com/1422-0067/23/8/4328

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https://www.mdpi.com/1422-0067/23/8/4328

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