Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

Abstract Background Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein. Recent studies have suggested that additional cell death pathways may interact with GSDMD under certain cir...

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Bibliographic Details
Main Authors: Brienne A. McKenzie, Jason P. Fernandes, Matthew A. L. Doan, Laura M. Schmitt, William G. Branton, Christopher Power
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Pyroptosis
Caspase
Inflammasome
Immunity
Central nervous system
Online Access:http://link.springer.com/article/10.1186/s12974-020-01902-5

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http://link.springer.com/article/10.1186/s12974-020-01902-5

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