Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation

Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation

GPR174 is a lysophosphatidylserine (LysoPS) activated GPCR. Here, the authors report the cryo-EM structure of LysoPS-bound human GPR174 in complex with Gs protein. The study reveals how GPR174 recognizes the lipid ligand and engages Gs in a distinct binding mode.

Bibliographic Details
Main Authors: Jiale Liang, Asuka Inoue, Tatsuya Ikuta, Ruixue Xia, Na Wang, Kouki Kawakami, Zhenmei Xu, Yu Qian, Xinyan Zhu, Anqi Zhang, Changyou Guo, Zhiwei Huang, Yuanzheng He
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36575-0

Internet

https://doi.org/10.1038/s41467-023-36575-0

Similar Items