Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation
GPR174 is a lysophosphatidylserine (LysoPS) activated GPCR. Here, the authors report the cryo-EM structure of LysoPS-bound human GPR174 in complex with Gs protein. The study reveals how GPR174 recognizes the lipid ligand and engages Gs in a distinct binding mode.
Bibliographic Details
| Main Authors: |
Jiale Liang,
Asuka Inoue,
Tatsuya Ikuta,
Ruixue Xia,
Na Wang,
Kouki Kawakami,
Zhenmei Xu,
Yu Qian,
Xinyan Zhu,
Anqi Zhang,
Changyou Guo,
Zhiwei Huang,
Yuanzheng He |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-36575-0
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