The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis

In this new study the Authors demonstrated that the IGFBP3/TMEM219 pathway is a physiological regulator of pancreatic beta cell homeostasis and it is dysregulated in diabetes. IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes.

Bibliographic Details
Main Authors: Francesca D’Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C. Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F. Markmann, Emanuela Orsi, Jan Škrha, Maria Gabriella Camboni, Reza Abdi, A. M. James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28360-2

Internet

https://doi.org/10.1038/s41467-022-28360-2

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