Semaglutide reduces tumor burden in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH-HCC with advanced fibrosis

Semaglutide reduces tumor burden in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH-HCC with advanced fibrosis

Abstract Non-alcoholic steatohepatitis (NASH) is emerging as a major cause of hepatocellular carcinoma (HCC), however, it is not resolved if compounds in late-stage clinical development for NASH may have additional therapeutic benefits in NASH-driven HCC (NASH-HCC). Here, we profiled monotherapy wit...

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Bibliographic Details
Main Authors: Henrik H. Hansen, Susanne Pors, Maja W. Andersen, Mogens Vyberg, Jacob Nøhr-Meldgaard, Malte Hasle Nielsen, Denise Oró, Martin Rønn Madsen, Monika Lewinska, Mathias B. Møllerhøj, Andreas Nygaard Madsen, Michael Feigh
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-50328-5

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https://doi.org/10.1038/s41598-023-50328-5

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