Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells

Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells

IntroductionELAVL1/HuR is a keystone regulator of gene expression at the posttranscriptional level, including stress response and homeostasis maintenance. The aim of this study was to evaluate the impact of hur silencing on the age-related degeneration of retinal ganglion cells (RGC), which potentia...

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Bibliographic Details
Main Authors: Anna Pacwa, Joanna Machowicz, Saeed Akhtar, Piotr Rodak, Xiaonan Liu, Marita Pietrucha-Dutczak, Joanna Lewin-Kowalik, Marialaura Amadio, Adrian Smedowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glaucoma
retinal ganglion cells (RGC)
RNA-binding protein
HuR (ELAVL1)
neuroprotection
AAV (adeno-associated virus)
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1131356/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1131356/full

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