In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity

In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity

Introduction: Obtaining triphenylphosphonium salts derived from anticancer compounds to inhibit mitochondrial metabolism is of major interest due to their pivotal role in reactive oxygen species (ROS) production, calcium homeostasis, apoptosis, and cell proliferation. However, the use of this type o...

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Bibliographic Details
Main Authors: Héctor Montecino-Garrido, Diego Méndez, Ramiro Araya-Maturana, Juan Pablo Millas-Vargas, Sergio Wehinger, Eduardo Fuentes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
platelet
cytotoxicity
antiplatelet
triphenylphosphonium
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.893873/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.893873/full

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