EPH/Ephrin Signaling in Normal Hematopoiesis and Hematologic Malignancies: Deciphering Their Intricate Role and Unraveling Possible New Therapeutic Targets

EPH/Ephrin Signaling in Normal Hematopoiesis and Hematologic Malignancies: Deciphering Their Intricate Role and Unraveling Possible New Therapeutic Targets

Erythropoietin-producing hepatocellular carcinoma receptors (EPHs) represent the largest family of receptor tyrosine kinases (RTKs). EPH interaction with ephrins, their membrane-bound ligands, holds a pivotal role in embryonic development, while, though less active, it is also implicated in various...

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Bibliographic Details
Main Authors: Ioanna E. Stergiou, Stavros P. Papadakos, Anna Karyda, Ourania E. Tsitsilonis, Meletios-Athanasios Dimopoulos, Stamatios Theocharis
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
EPHs
ephrins
hematopoiesis
hematologic malignancies
therapeutic targeting
Online Access:https://www.mdpi.com/2072-6694/15/15/3963

Internet

https://www.mdpi.com/2072-6694/15/15/3963

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