Real-Time TDM-Guided Optimal Joint PK/PD Target Attainment of Continuous Infusion Piperacillin–Tazobactam Monotherapy Is an Effective Carbapenem-Sparing Strategy for Treating Non-Severe ESBL-Producing <i>Enterobacterales</i> Secondary Bloodstream Infections: Findings from a Prospective Pilot Study

Real-Time TDM-Guided Optimal Joint PK/PD Target Attainment of Continuous Infusion Piperacillin–Tazobactam Monotherapy Is an Effective Carbapenem-Sparing Strategy for Treating Non-Severe ESBL-Producing <i>Enterobacterales</i> Secondary Bloodstream Infections: Findings from a Prospective Pilot Study

(1) Objectives: To assess the impact of optimal joint pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin–tazobactam monotherapy on the microbiological outcome of documented ESBL-producing <i>Enterobacterlaes</i> secondary bloodstream infect...

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Bibliographic Details
Main Authors: Milo Gatti, Cecilia Bonazzetti, Renato Pascale, Maddalena Giannella, Pierluigi Viale, Federico Pea
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Microorganisms
Subjects:
ESBL-producing <i>Enterobacterales</i>
bloodstream infections
piperacillin–tazobactam
continuous infusion
optimal joint PK/PD target attainment
microbiological eradication
Online Access:https://www.mdpi.com/2076-2607/12/1/151

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https://www.mdpi.com/2076-2607/12/1/151

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