Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction

Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, offers renoprotection in diabetes. However, potential for use in nondiabetic kidney disease remains unknown. Herein, we assessed whether dapagliflozin alleviates renal fibrosis by interfering with necroinflammation in a rat model of unilater...

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Bibliographic Details
Main Authors: Mei Ying Xuan, Shang Guo Piao, Jun Ding, Qi Yan Nan, Mei Hua Piao, Yu Ji Jiang, Hai Lan Zheng, Ji Zhe Jin, Can Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
dapagliflozin
unilateral ureteral obstruction
necroinflammation
oxidative stress
endoplasmic reticulum stress
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.798381/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.798381/full

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