CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories

CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories

Summary: Mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are a frequent cause of autism spectrum disorder (ASD). While its phenotypic spectrum often encompasses macrocephaly, implicating cortical abnormalities, how CHD8 haploinsufficiency affects neurodevelopmental is unclear. Here,...

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Bibliographic Details
Main Authors: Carlo Emanuele Villa, Cristina Cheroni, Christoph P. Dotter, Alejandro López-Tóbon, Bárbara Oliveira, Roberto Sacco, Aysan Çerağ Yahya, Jasmin Morandell, Michele Gabriele, Mojtaba R. Tavakoli, Julia Lyudchik, Christoph Sommer, Mariano Gabitto, Johann G. Danzl, Giuseppe Testa, Gaia Novarino
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722003631

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http://www.sciencedirect.com/science/article/pii/S2211124722003631

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