Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo

Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo

Abstract Objective We had previously reported a mouse line carrying the Atypical female courtship (HoxD Afc ) allele, where an ectopic accumulation of Hoxd10 transcripts was observed in a sparse population of cells in the adult isocortex, as a result of a partial deletion of the HoxD gene cluster. F...

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Bibliographic Details
Main Authors: Jozsef Zakany, Denis Duboule
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Research Notes
Subjects:
Social behavior
Hippocampus
HOXD10
Genome editing
CRISPR/Cas9
Online Access:http://link.springer.com/article/10.1186/s13104-018-3307-8

Internet

http://link.springer.com/article/10.1186/s13104-018-3307-8

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