Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

Background and aim: The liver is susceptible to ischemia-reperfusion injury (IRI) during hepatic surgery, when the vessels are compressed to control bleeding, or liver transplantation, when there is an obligate period of ischemia. The hallmark of IRI comprises mitochondrial dysfunction, which genera...

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Bibliographic Details
Main Authors: Joshua Hefler, Rena Pawlick, Braulio A. Marfil-Garza, Aducio Thiesen, Nerea Cuesta-Gomez, Sanaz Hatami, Darren H. Freed, Constantine Karvellas, David L. Bigam, A.M. James Shapiro
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Liver Research
Subjects:
Cyclosporine (CsA)
Cyclosporine analogue
Liver surgery
Ischemia-reperfusion injury (IRI)
Animal model
NIM-811
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568424000047

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http://www.sciencedirect.com/science/article/pii/S2542568424000047

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