Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

Abstract Background Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefore a promising target for GBM treatment. Our group identified the cellu...

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Bibliographic Details
Main Authors: Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Lilian Cruz, Vilma Regina Martins, Tiago Góss Santos, Marilene Hohmuth Lopes
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Stem Cell Research & Therapy
Subjects:
Cellular prion protein
Hsp70/90 organizing protein
Glioblastoma
Stem cells
Proliferation
Online Access:http://link.springer.com/article/10.1186/s13287-017-0518-1

Internet

http://link.springer.com/article/10.1186/s13287-017-0518-1

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