Cytoplasmically Retargeted HSV1-tk/GFP Reporter Gene Mutants for Optimization of Noninvasive Molecular-Genetic Imaging

To optimize the sensitivity of imaging HSV1-tk/GFP reporter gene expression, a series of HSV1-tk/GFP mutants was developed with altered nuclear localization and better cellular enzymatic activity, compared to that of the native HSV1-tk/GFP fusion protein (HSVi-tk/GFP). Several modifications of HSV1-...

Full description

Bibliographic Details
Main Authors: Vladimir Ponomarev, Michael Doubrovin, Inna Serganova, Tatiana Beresten, Jelena Vider, Aleksander Shavrin, Ludmila Ageyeva, Julius Balatoni, Ronald Blasberg, Juri Gelovani Tjuvajev
Format: Article
Language:English
Published: Elsevier 2003-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800568