Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report
A young male clove cigarette smoker experienced spontaneous pneumothorax and later paraseptal emphysema was detected on high-resolution computed tomography (HRCT) scan without respiratory symptoms. Smoking is a known risk factor for emphysema. Paraseptal emphysema is a type of emphysema that rarely...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007120302197 |
| _version_ | 1819319774926077952 |
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| author | Winariani Koesoemoprodjo Daniel Maranatha |
| author_facet | Winariani Koesoemoprodjo Daniel Maranatha |
| author_sort | Winariani Koesoemoprodjo |
| collection | DOAJ |
| description | A young male clove cigarette smoker experienced spontaneous pneumothorax and later paraseptal emphysema was detected on high-resolution computed tomography (HRCT) scan without respiratory symptoms. Smoking is a known risk factor for emphysema. Paraseptal emphysema is a type of emphysema that rarely causes respiratory symptoms, nevertheless, usually accompanied by spontaneous pneumothorax.Interleukin 33 (IL-33) is an alarmin cytokine that belongs to the IL-1 family. The effects of IL-33 depend on its structure. In its mature form, it is a cytokine alarmin that binds to ST2 (suppression of tumorigenicity) receptors on the surface of macrophages and innate immune cells to drive Th1/Th2 immune responses, causing oxidative stress, and increased IL-33 production causes polarization of alveolar macrophages to an M2 phenotype.In this study, long-term exposure to clove cigarette smoke caused an increased serum level of IL-33 (43.72 pg/mL) and paucigranulocytic airway inflammation. In paucigranulocytic inflammation, IL-33 is involved in lung parenchymal damage presumably through oxidative stress, activation of alveolar macrophage and increased MMP12 secretion, resulting in alveolar destruction and airspace enlargement. |
| first_indexed | 2024-12-24T11:09:02Z |
| format | Article |
| id | doaj.art-6946f24e3cfd4637b754f74ed14d6b0e |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-24T11:09:02Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-6946f24e3cfd4637b754f74ed14d6b0e2022-12-21T16:58:35ZengElsevierRespiratory Medicine Case Reports2213-00712020-01-0130101133Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case reportWinariani Koesoemoprodjo0Daniel Maranatha1Department of Pulmonology and Respiratory Disease, Faculty of Medicine, Airlangga University - Dr Soetomo Academic Hospital, IndonesiaCorresponding author. Department of Pulmonology and Respiratory Medicine Department, Faculty of Medicine, Airlangga University, Dr.Soetomo General Hospital Jl. Prof.Dr.Moestopo 6-8 Surabaya, 60182, Indonesia.; Department of Pulmonology and Respiratory Disease, Faculty of Medicine, Airlangga University - Dr Soetomo Academic Hospital, IndonesiaA young male clove cigarette smoker experienced spontaneous pneumothorax and later paraseptal emphysema was detected on high-resolution computed tomography (HRCT) scan without respiratory symptoms. Smoking is a known risk factor for emphysema. Paraseptal emphysema is a type of emphysema that rarely causes respiratory symptoms, nevertheless, usually accompanied by spontaneous pneumothorax.Interleukin 33 (IL-33) is an alarmin cytokine that belongs to the IL-1 family. The effects of IL-33 depend on its structure. In its mature form, it is a cytokine alarmin that binds to ST2 (suppression of tumorigenicity) receptors on the surface of macrophages and innate immune cells to drive Th1/Th2 immune responses, causing oxidative stress, and increased IL-33 production causes polarization of alveolar macrophages to an M2 phenotype.In this study, long-term exposure to clove cigarette smoke caused an increased serum level of IL-33 (43.72 pg/mL) and paucigranulocytic airway inflammation. In paucigranulocytic inflammation, IL-33 is involved in lung parenchymal damage presumably through oxidative stress, activation of alveolar macrophage and increased MMP12 secretion, resulting in alveolar destruction and airspace enlargement.http://www.sciencedirect.com/science/article/pii/S2213007120302197Paraseptal emphysema. paucigranulocytic airway inflammation. IL-33 |
| spellingShingle | Winariani Koesoemoprodjo Daniel Maranatha Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report Respiratory Medicine Case Reports Paraseptal emphysema. paucigranulocytic airway inflammation. IL-33 |
| title | Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report |
| title_full | Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report |
| title_fullStr | Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report |
| title_full_unstemmed | Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report |
| title_short | Level of serum IL-33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax: A case report |
| title_sort | level of serum il 33 and emphysema paraseptal in clove cigarette smoker with spontaneous pneumothorax a case report |
| topic | Paraseptal emphysema. paucigranulocytic airway inflammation. IL-33 |
| url | http://www.sciencedirect.com/science/article/pii/S2213007120302197 |
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