Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis

IntroductionThe pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell types that highly expresses IL-23R are colonic regulatory T cells (Treg ce...

Full description

Bibliographic Details
Main Authors: Justin Jacobse, Jennifer M. Pilat, Jing Li, Rachel E. Brown, Aaron Kwag, Matthew A. Buendia, Yash A. Choksi, M. Kay Washington, Christopher S. Williams, Nicholas O. Markham, Sarah P. Short, Jeremy A. Goettel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1276743/full