Ultramicronized <i>N</i>-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance

Ultramicronized <i>N</i>-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance

Persistent pain can be managed with opioids, but their use is limited by the onset of tolerance. Ultramicronized <i>N</i>-palmitoylethanolamine (PEA) in vivo delays morphine tolerance with mechanisms that are still unclear. Since glial cells are involved in opioid tolerance and mast cell...

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Bibliographic Details
Main Authors: Alessandra Toti, Laura Micheli, Elena Lucarini, Valentina Ferrara, Clara Ciampi, Francesco Margiotta, Paola Failli, Chiara Gomiero, Marco Pallecchi, Gianluca Bartolucci, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomolecules
Subjects:
morphine
tolerance
<i>N</i>-palmitoylethanolamine
mast cell
glial cells
cross-talk
Online Access:https://www.mdpi.com/2218-273X/13/2/233

Internet

https://www.mdpi.com/2218-273X/13/2/233

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