Impact of cfDNA Reference Materials on Clinical Performance of Liquid Biopsy NGS Assays

Impact of cfDNA Reference Materials on Clinical Performance of Liquid Biopsy NGS Assays

Background: Liquid biopsy enables the non-invasive analysis of genetic tumor variants in circulating free DNA (cfDNA) in plasma. Accurate analytical validation of liquid biopsy NGS assays is required to detect variants with low variant allele frequencies (VAFs). Methods: Six types of commercial cfDN...

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Bibliographic Details
Main Authors: Ariane Hallermayr, Thomas Keßler, Moritz Fujera, Ben Liesfeld, Samuel Bernstein, Simon von Ameln, Denny Schanze, Verena Steinke-Lange, Julia M. A. Pickl, Teresa M. Neuhann, Elke Holinski-Feder
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
ctDNA
duplex sequencing
cfDNA reference materials
validation
cancer
mosaic disease
Online Access:https://www.mdpi.com/2072-6694/15/20/5024

Internet

https://www.mdpi.com/2072-6694/15/20/5024

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