Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice

Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice

Background: Inflammation and reactive oxygen species (ROS) are important in the development of perinatal brain injury. The ROS-generating enzyme NADPH oxidase (Nox2) is present in inflammatory cells and contributes to brain injury in adult animal models. Hypothesis: NADPH oxidase contributes to ROS...

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Bibliographic Details
Main Authors: Christina Doverhag, Matthias Keller, Anna Karlsson, Maj Hedtjarn, Ulf Nilsson, Edith Kapeller, Gergely Sarkozy, Lars Klimaschewski, Christian Humpel, Henrik Hagberg, Georg Simbruner, Pierre Gressens, Karin Savman
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Neurobiology of Disease
Subjects:
Brain injury
Newborn
Hypoxia–ischemia
Excitoxicity
NADPH oxidase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000727

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http://www.sciencedirect.com/science/article/pii/S0969996108000727

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