TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and NF-κB/MAPK Signaling in Transgenic Mammal Models

TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and NF-κB/MAPK Signaling in Transgenic Mammal Models

Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and induces innate immune responses, autophagy, and cell death, which have major impacts on the body’s physiological homeostasis. However, the role...

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Dettagli Bibliografici
Autori principali: Sutian Wang, Kunli Zhang, Xuting Song, Qiuyan Huang, Sen Lin, Shoulong Deng, Meiyu Qi, Yecheng Yang, Qi Lu, Duowei Zhao, Fanming Meng, Jianhao Li, Zhengxing Lian, Chenglong Luo, Yuchang Yao
Natura: Articolo
Lingua:English
Pubblicazione: MDPI AG 2023-07-01
Serie:Cells
Soggetti:
Toll-like receptor 4
transgenic animal model
autophagy
apoptosis
inflammation
oxidative stress
Accesso online:https://www.mdpi.com/2073-4409/12/13/1769

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https://www.mdpi.com/2073-4409/12/13/1769

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