Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Abstract Background Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. Inhibition of heat shock protein 90 (HSP90), a conserved molecular c...

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Bibliographic Details
Main Authors: Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
Triple-negative breast cancer
TNBC
Breast cancer
Heat shock protein
HSP90
Ganetespib
Online Access:http://link.springer.com/article/10.1186/s12885-019-5295-z

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http://link.springer.com/article/10.1186/s12885-019-5295-z

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