Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection.

We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse model of sub-acute Mycobacterium tuberculosis infection. Pharmacokinetic metrics for such small mole...

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Bibliographic Details
Main Authors: Ravindra Jadhav, Ricardo Gallardo-Macias, Gaurav Kumar, Samer S Daher, Amit Kaushik, Kristina M Bigelow, Eric L Nuermberger, Gyanu Lamichhane, Joel S Freundlich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0249841