Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection.
We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse model of sub-acute Mycobacterium tuberculosis infection. Pharmacokinetic metrics for such small mole...
Main Authors: | Ravindra Jadhav, Ricardo Gallardo-Macias, Gaurav Kumar, Samer S Daher, Amit Kaushik, Kristina M Bigelow, Eric L Nuermberger, Gyanu Lamichhane, Joel S Freundlich |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0249841 |
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