Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells.

Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells.

The PI3K/Akt pathway is interconnected to protein kinase CK2, which directly phosphorylates Akt1 at S129. We have previously found that, in HK-2 renal cells, downregulation of the CK2 regulatory subunit β (shCK2β cells) reduces S129 Akt phosphorylation. Here, we investigated in more details how the...

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Bibliographic Details
Main Authors: Estefania Alcaraz, Jordi Vilardell, Christian Borgo, Eduard Sarró, Maria Plana, Oriano Marin, Lorenzo A Pinna, José R Bayascas, Anna Meseguer, Mauro Salvi, Emilio Itarte, Maria Ruzzene
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0227340

Internet

https://doi.org/10.1371/journal.pone.0227340

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