Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation

Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation

Toll-like receptor 2 (TLR2) mediated macrophages regulate the protective immune response to infectious microorganisms, but the aberrant activation of macrophages often leads to pathological inflammation, including tissue damage. In this study, we identified antagonists of TLR2 by screening 2100 natu...

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Bibliographic Details
Main Authors: Junjie Yang, Yue Pan, Xiaoshan Zeng, Shuwen Liu, Zhipeng Chen, Kui Cheng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Taspine derivative
TLR2 inhibitor
MyD88, NF-κB signaling pathway
Macrophage polarization
Anti-acute inflammatory
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001971

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http://www.sciencedirect.com/science/article/pii/S2211383523001971

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