ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES
The analgesic activity of the series of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones substituted in position 3 was studied. As a leader, it was revealed the compound 8 (3-propoxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one) with ED50 value of 0,030 ± 0,007 mg/kg, which also has dem...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Odessa I. I. Mechnikov National University
2014-11-01
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| Series: | Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ |
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| Online Access: | http://heraldchem.onu.edu.ua/article/view/31120 |
| _version_ | 1830349387613601792 |
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| author | V. I. Pavlovsky T. A. Kabanova E. I. Khalimova S. A. Andronati |
| author_facet | V. I. Pavlovsky T. A. Kabanova E. I. Khalimova S. A. Andronati |
| author_sort | V. I. Pavlovsky |
| collection | DOAJ |
| description | The analgesic activity of the series of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones substituted in position 3 was studied. As a leader, it was revealed the compound 8 (3-propoxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one) with ED50 value of 0,030 ± 0,007 mg/kg, which also has demonstrated in vivo anti-inflammatory activity in rats. |
| first_indexed | 2024-12-20T00:02:57Z |
| format | Article |
| id | doaj.art-6955fb29579a48ba839bc80c8f0c1310 |
| institution | Directory Open Access Journal |
| issn | 2304-0947 2414-5963 |
| language | English |
| last_indexed | 2024-12-20T00:02:57Z |
| publishDate | 2014-11-01 |
| publisher | Odessa I. I. Mechnikov National University |
| record_format | Article |
| series | Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ |
| spelling | doaj.art-6955fb29579a48ba839bc80c8f0c13102022-12-21T20:00:46ZengOdessa I. I. Mechnikov National UniversityVìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ2304-09472414-59632014-11-01183(47)283710.18524/2304-0947.2013.3(47).3112031120ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONESV. I. Pavlovsky0T. A. Kabanova1E. I. Khalimova2S. A. Andronati3Фізико-хімічний інститут ім. О. В. Богатського Національної академії наук УкраїниФізико-хімічний інститут ім. О. В. Богатського Національної академії наук УкраїниФізико-хімічний інститут ім. О. В. Богатського Національної академії наук УкраїниФізико-хімічний інститут ім. О. В. Богатського Національної академії наук УкраїниThe analgesic activity of the series of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones substituted in position 3 was studied. As a leader, it was revealed the compound 8 (3-propoxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one) with ED50 value of 0,030 ± 0,007 mg/kg, which also has demonstrated in vivo anti-inflammatory activity in rats.http://heraldchem.onu.edu.ua/article/view/311203-заміщені 1,4-бенздіазепінианальгезіянабряк |
| spellingShingle | V. I. Pavlovsky T. A. Kabanova E. I. Khalimova S. A. Andronati ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ 3-заміщені 1,4-бенздіазепіни анальгезія набряк |
| title | ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES |
| title_full | ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES |
| title_fullStr | ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES |
| title_full_unstemmed | ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES |
| title_short | ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES OF THE NOVEL 3– ALKOXY -1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2- ONES |
| title_sort | analgesic and anti inflammatory properties of the novel 3 alkoxy 1 2 dihydro 3h 1 4 benzodiazepin 2 ones |
| topic | 3-заміщені 1,4-бенздіазепіни анальгезія набряк |
| url | http://heraldchem.onu.edu.ua/article/view/31120 |
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