Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach

Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach

Tumour hypoxia has been associated with increased resistance to various cancer treatments, particularly radiation therapy. Conversely, tumour hypoxia is a validated and ideal target for guided cancer drug delivery. For this reason, hypoxia-activated prodrugs (HAPs) have been developed, which remain...

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Bibliographic Details
Main Authors: Cameron Meaney, Gibin G Powathil, Ala Yaromina, Ludwig J Dubois, Philippe Lambin, Mohammad Kohandel
Format: Article
Language:English
Published: AIMS Press 2019-07-01
Series:Mathematical Biosciences and Engineering
Subjects:
cancer
mathematical oncology
drug response
multiscale model
radiation; hypoxia
hypoxia-activated prodrugs
Online Access:https://www.aimspress.com/article/10.3934/mbe.2019312?viewType=HTML

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https://www.aimspress.com/article/10.3934/mbe.2019312?viewType=HTML

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