Clinical Pharmacokinetic Assessment of Kratom (<i>Mitragyna speciosa</i>), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

Clinical Pharmacokinetic Assessment of Kratom (<i>Mitragyna speciosa</i>), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants

Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous fundamental pharmacokinetic knowledge of kratom in humans remains lacking. We assessed the pharmacokinetics of a single...

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Bibliographic Details
Main Authors: Rakshit S. Tanna, James T. Nguyen, Deena L. Hadi, Preston K. Manwill, Laura Flores-Bocanegra, Matthew E. Layton, John R. White, Nadja B. Cech, Nicholas H. Oberlies, Allan E. Rettie, Kenneth E. Thummel, Mary F. Paine
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
clinical trials
pharmacokinetics
botanicals
opioids
kratom
compartmental modeling
Online Access:https://www.mdpi.com/1999-4923/14/3/620

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https://www.mdpi.com/1999-4923/14/3/620

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