Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic target, given PAR4 seems...

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Bibliographic Details
Main Authors: Rachel A. Rigg, Laura D. Healy, Tiffany T. Chu, Anh T. P. Ngo, Annachiara Mitrugno, Jevgenia Zilberman-Rudenko, Joseph E. Aslan, Monica T. Hinds, Lisa Dirling Vecchiarelli, Terry K. Morgan, András Gruber, Kayla J. Temple, Craig W. Lindsley, Matthew T. Duvernay, Heidi E. Hamm, Owen J. T. McCarty
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Platelets
Subjects:
par4
platelet-leukocyte interactions
platelet dense granule release
platelet activation
protease-activated receptor 4
granulocytes
Online Access:http://dx.doi.org/10.1080/09537104.2017.1406076

Internet

http://dx.doi.org/10.1080/09537104.2017.1406076

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