DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination

DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination

BackgroundAdvanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet medical need. We demonstrated that the alkylating agent trabectedin and the PARP1-inhibitor olaparib display antitumor activity in BSTS preclinical models. Moreover, in a phase Ib clinical trial (NCT023...

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Main Authors: Alessandra Merlini, Maria Laura Centomo, Giulio Ferrero, Giulia Chiabotto, Umberto Miglio, Enrico Berrino, Giorgia Giordano, Silvia Brusco, Alberto Pisacane, Elena Maldi, Ivana Sarotto, Federica Capozzi, Cristina Lano, Claudio Isella, Giovanni Crisafulli, Massimo Aglietta, Angelo Paolo Dei Tos, Marta Sbaraglia, Dario Sangiolo, Lorenzo D’Ambrosio, Alberto Bardelli, Ymera Pignochino, Giovanni Grignani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
bone and soft tissue sarcomas
predictive biomarkers
DNA damage response and repair genes
trabectedin
olaparib
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.844250/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.844250/full

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