Disruption of Crystal Packing in Thieno[2,3-<i>b</i>]pyridines Improves Anti-Proliferative Activity

Disruption of Crystal Packing in Thieno[2,3-<i>b</i>]pyridines Improves Anti-Proliferative Activity

3-Amino-2-arylcarboxamido-thieno[2,3-<i>b</i>]pyridines have been shown to have anti-proliferative activity, but are also known to have poor solubility. This has been previously proposed to be due to their extensive planarity, which allows for intermolecular stacking and crystal packing....

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Bibliographic Details
Main Authors:	Natalie A. Haverkate, Euphemia Leung, Lisa I. Pilkington, David Barker
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	Molecules
Subjects:	thieno[2,3-<i>b</i>]pyridines esters anti-proliferative prodrugs
Online Access:	https://www.mdpi.com/1420-3049/27/3/836

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