TGF-β and TNF-α interaction promotes the expression of MMP-9 through H3K36 dimethylation: implications in breast cancer metastasis

TGF-β and TNF-α interaction promotes the expression of MMP-9 through H3K36 dimethylation: implications in breast cancer metastasis

Increased MMP-9 expression in the tumor microenvironment (TME) plays a crucial role in the extracellular matrix remodeling to facilitate cancer invasion and metastasis. However, the mechanism of MMP-9 upregulation in TME remains elusive. Since TGF-β and TNF-α levels are elevated in TME, we asked whe...

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Bibliographic Details
Main Authors: Shihab Kochumon, Amnah Al-Sayyar, Texy Jacob, Fatemah Bahman, Nadeem Akhter, Ajit Wilson, Sardar Sindhu, Yusuf A. Hannun, Rasheed Ahmad, Fahd Al-Mulla
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
histone methylation
H3K36me2
MMP-9
Smad2/3
TNF-α
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430187/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430187/full

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