Prolactin Rescues Immature B Cells from Apoptosis-Induced BCR-Aggregation through STAT3, Bcl2a1a, Bcl2l2, and Birc5 in Lupus-Prone MRL/lpr Mice

Prolactin Rescues Immature B Cells from Apoptosis-Induced BCR-Aggregation through STAT3, Bcl2a1a, Bcl2l2, and Birc5 in Lupus-Prone MRL/lpr Mice

Self-reactive immature B cells are eliminated through apoptosis by tolerance mechanisms, failing to eliminate these cells results in autoimmune diseases. Prolactin is known to rescue immature B cells from B cell receptor engagement-induced apoptosis in lupus-prone mice. The objective of this study w...

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Bibliographic Details
Main Authors: Rocio Flores-Fernández, Angélica Aponte-López, Mayra C. Suárez-Arriaga, Patricia Gorocica-Rosete, Alberto Pizaña-Venegas, Luis Chávez-Sanchéz, Francico Blanco-Favela, Ezequiel M. Fuentes-Pananá, Adriana K. Chávez-Rueda
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
prolactin receptor
prolactin
immature B cells
STAT3
Birc5
Bcl2a1a
Online Access:https://www.mdpi.com/2073-4409/10/2/316

Internet

https://www.mdpi.com/2073-4409/10/2/316

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