CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

Summary: Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for cancer therapies. We performed a genome-wide CRISPR-Cas9 cell viability screen at physiologic...

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Detalhes bibliográficos
Principais autores: Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2022-03-01
coleção:Cell Reports
Assuntos:
tumor acidity
acidosis
CRISPR-Cas9 screen
oxidative phosphorylation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124722002261

Internet

http://www.sciencedirect.com/science/article/pii/S2211124722002261

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