A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the mechanical obstruction of the microcirculation by poorly deformable red blood cells (RBCs). RBC deformability is a key factor in...

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Bibliographic Details
Main Authors: Evrim Goksel, Elif Ugurel, Elie Nader, Camille Boisson, Ingrid Muniansi, Philippe Joly, Celine Renoux, Alexandra Gauthier, Philippe Connes, Ozlem Yalcin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Physiology
Subjects:
sickle cell disease
deformability
shear stress
adenylyl cyclase
phosphodiesterases
protein kinase A
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1215835/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1215835/full

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