Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

The mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation, migration, and survival, as well as angiogenesis and metabolism. Dysregulation of these pathways is frequently associat...

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Bibliographic Details
Main Authors: Jean Christopher Chamcheu, Tithi Roy, Mohammad Burhan Uddin, Sergette Banang-Mbeumi, Roxane-Cherille N. Chamcheu, Anthony L. Walker, Yong-Yu Liu, Shile Huang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
PI3K
Akt
mTOR
skin cancers
phytochemicals
melanoma
basal cell carcinoma
squamous cell carcinoma
Merkel cell carcinoma
targeted therapy
Online Access:https://www.mdpi.com/2073-4409/8/8/803

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https://www.mdpi.com/2073-4409/8/8/803

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