PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence

Quiescent stem cells are activated in response to a mechanical or chemical injury to their tissue niche. Activated cells rapidly generate a heterogeneous progenitor population that regenerates the damaged tissues. While the transcriptional cadence that generates heterogeneity is known, the metabolic...

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Bibliographic Details
Main Authors: Michael Xiao, Chia-Hua Wu, Graham Meek, Brian Kelly, Dara Buendia Castillo, Lyndsay EA Young, Sara Martire, Sajina Dhungel, Elizabeth McCauley, Purbita Saha, Altair L Dube, Matthew S Gentry, Laura A Banaszynski, Ramon C Sun, Chintan K Kikani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
Pax7
self-renewal
PASK
glutamine
myogenesis
Wdr5
Online Access:https://elifesciences.org/articles/81717

Internet

https://elifesciences.org/articles/81717

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