Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module

Nonribosomal peptide synthetases work with additional enzymes to synthesise secondary metabolites and therapeutics. Here, the authors explore bacillamide D synthesis and show the oxidase action is done while the intermediate is attached to the synthetase and replicate this with an oxidase bound synt...

Full description

Bibliographic Details
Main Authors: Camille Marie Fortinez, Kristjan Bloudoff, Connor Harrigan, Itai Sharon, Mike Strauss, T. Martin Schmeing
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28221-y