SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress

SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress

Uncontrolled accumulation of methylglyoxal (MG) and reactive oxygen species (ROS) occurs in hyperglycemia-induced endothelial dysfunction associated with diabetes. Resveratrol (RSV) protects the endothelium upon high glucose (HG); however, the mechanisms underlying such protective effects are still...

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Bibliographic Details
Main Authors: Silvano Junior Santini, Valeria Cordone, Mahmut Mijit, Virginio Bignotti, Pierpaolo Aimola, Vincenza Dolo, Stefano Falone, Fernanda Amicarelli
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antioxidants
Subjects:
oxidative stress
glycative stress
dicarbonyl stress
antioxidant defense
superoxide dismutase
catalase
glyoxalase
EX527
sirtuin 1
Online Access:https://www.mdpi.com/2076-3921/8/9/346

Internet

https://www.mdpi.com/2076-3921/8/9/346

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