Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production

Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production

Previously, a designed ankyrin repeat protein, Ank<sup>GAG</sup>1D4, was generated for intracellular targeting of the HIV-1 capsid domain. The efficiency was satisfactory in interfering with the HIV assembly process. Consequently, improved Ank<sup>GAG</sup>1D4 binding affinit...

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Bibliographic Details
Main Authors: Kanokporn Sornsuwan, Weeraya Thongkhum, Thanathat Pamonsupornwichit, Tanawan Samleerat Carraway, Suthinee Soponpong, Supachai Sakkhachornphop, Chatchai Tayapiwatana, Umpa Yasamut
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomolecules
Subjects:
ankyrin
capsid
HIV-1 assembly
anti-HIV-1 molecule
HIV-1 drug resistance
Online Access:https://www.mdpi.com/2218-273X/11/10/1437

Internet

https://www.mdpi.com/2218-273X/11/10/1437

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