Interdependence of Molecular Lesions That Drive Uveal Melanoma Metastasis

Interdependence of Molecular Lesions That Drive Uveal Melanoma Metastasis

The metastatic risk of uveal melanoma (UM) is defined by a limited number of molecular lesions, somatic mutations (SF3B1 and BAP1), and copy number alterations (CNA): monosomy of chromosome 3 (M3), chr8q gain (8q), chr6p gain (6p), yet the sequence of events is not clear. We analyzed data from three...

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Bibliographic Details
Main Authors: Francesco Reggiani, Marianna Ambrosio, Michela Croce, Enrica Teresa Tanda, Francesco Spagnolo, Edoardo Raposio, Mariangela Petito, Zeinab El Rashed, Alessandra Forlani, Ulrich Pfeffer, Adriana Agnese Amaro
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
uveal melanoma
metastases
gene expression
BAP1
CNA
tumor evolution
Online Access:https://www.mdpi.com/1422-0067/24/21/15602

Internet

https://www.mdpi.com/1422-0067/24/21/15602

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