MegaPath: sensitive and rapid pathogen detection using metagenomic NGS data

MegaPath: sensitive and rapid pathogen detection using metagenomic NGS data

Abstract Background Next-generation sequencing (NGS) enables unbiased detection of pathogens by mapping the sequencing reads of a patient sample to the known reference sequence of bacteria and viruses. However, for a new pathogen without a reference sequence of a close relative, or with a high load...

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Bibliographic Details
Main Authors: Chi-Ming Leung, Dinghua Li, Yan Xin, Wai-Chun Law, Yifan Zhang, Hing-Fung Ting, Ruibang Luo, Tak-Wah Lam
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Genomics
Subjects:
Pathogen detection
Shotgun metagenomic sequencing
Next generation sequencing
Abundance detection
Read alignment
Online Access:https://doi.org/10.1186/s12864-020-06875-6

Internet

https://doi.org/10.1186/s12864-020-06875-6

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