Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms

Abstract Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyrosine phosphorylation and interaction with Crk ada...

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Bibliographic Details
Main Authors: Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cell Communication and Signaling
Subjects:
Ras-associated protein 1
RapGEF1
Signal transduction
Tyrosine phosphorylation
Src-homology 2 domain
Src-homology 3 domain
Online Access:https://doi.org/10.1186/s12964-023-01042-2

Internet

https://doi.org/10.1186/s12964-023-01042-2

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